A study of PAF‐induced ocular inflammation in the rat and its inhibition by the PAF antagonist, L‐652, 731
Identifieur interne : 003361 ( Main/Exploration ); précédent : 003360; suivant : 003362A study of PAF‐induced ocular inflammation in the rat and its inhibition by the PAF antagonist, L‐652, 731
Auteurs : P. D. Gautheron [France] ; L. Coulbault [France] ; M. F. Sugrue [France]Source :
- Journal of Pharmacy and Pharmacology [ 0022-3573 ] ; 1987-10.
English descriptors
- Teeft :
- Agents actions, Bisdesethylchloroquine, Chloroquine, Conjunctiva, Conjunctival, Conjunctival inflammation, Desethylchloroquine, Dohme research laboratories, Dos, Excretion, Goldenberg meurer, Indomethacin, Inflammation, Inflammatory, Inflammatory response, Oral administration, Parent compound, Pharm, Pharmacol, Pretreatment, Receptor, Receptor antagonist, Significant blockade, Significant reduction, Subconjunctival, Subconjunctival injection, Subconjunctivally, Tissue distribution, Tissue weight, Topical administration, Upper conjunctiva, Urinary excretion.
Abstract
A significant inflammatory reaction in the rat conjunctiva followed the subconjunctival injection of synthetic platelet activating factor (PAF) in doses which ranged from 10 ng to 1 μg, an inflammatory response being evaluated as the increase in both tissue weight and extravasation of Evans blue dye in the conjunctival tissue. Inflammation was still present 6 h after the injection of 0ṁ1 μg of PAF. Orally administered indomethacin or BW 755C failed to alter the response to 0ṁ1 μg of PAF. In contrast, the PAF‐induced inflammation was blocked by the oral administration of the PAF receptor antagonist, L‐652, 731, a dose as low as 5 mg kg−1 eliciting a significant inhibition. The topical administration of L‐652, 731, (two doses of 100 μg as a 1% suspension), elicited a slight, but significant blockade of 23%. Its antagonistic action was more striking when it was co‐injected subconjunctivally with 0ṁ1 μg of PAF, a dose as low as 3 μg evoking a significant blockade. The topical administration of 0ṁ1 μg of PAF did not elicit a significant inflammatory reaction and this contrasts with the results obtained after its subconjunctival injection.
Url:
DOI: 10.1111/j.2042-7158.1987.tb05135.x
Affiliations:
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Inflammation was still present 6 h after the injection of 0ṁ1 μg of PAF. Orally administered indomethacin or BW 755C failed to alter the response to 0ṁ1 μg of PAF. In contrast, the PAF‐induced inflammation was blocked by the oral administration of the PAF receptor antagonist, L‐652, 731, a dose as low as 5 mg kg−1 eliciting a significant inhibition. The topical administration of L‐652, 731, (two doses of 100 μg as a 1% suspension), elicited a slight, but significant blockade of 23%. Its antagonistic action was more striking when it was co‐injected subconjunctivally with 0ṁ1 μg of PAF, a dose as low as 3 μg evoking a significant blockade. The topical administration of 0ṁ1 μg of PAF did not elicit a significant inflammatory reaction and this contrasts with the results obtained after its subconjunctival injection.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region><settlement><li>Riom</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Gautheron, P D" sort="Gautheron, P D" uniqKey="Gautheron P" first="P. D." last="Gautheron">P. D. Gautheron</name></region><name sortKey="Coulbault, L" sort="Coulbault, L" uniqKey="Coulbault L" first="L." last="Coulbault">L. Coulbault</name><name sortKey="Gautheron, P D" sort="Gautheron, P D" uniqKey="Gautheron P" first="P. D." last="Gautheron">P. D. Gautheron</name><name sortKey="Sugrue, M F" sort="Sugrue, M F" uniqKey="Sugrue M" first="M. F." last="Sugrue">M. F. 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